http://www.ptemag.com/pharmtecheurope A publication featuring peer-reviewed technical articles on all aspects of pharmaceutical and biopharmaceutical manufacture. Subjects include solid dosage, drug delivery, packaging, raw materials, clean rooms and IT applications, supported by regulatory columns from Brussels and Washington. Information on products and literature used in drug manufacturing, as well as industry news, are also provided. 2008-10-06T15:38:14Z http://www.ptemag.com/pharmtecheurope/Validation/Quality-by-Design-for-analytical-methods-for-use-w/ArticleStandard/Article/detail/553258?ref=25 The design of accurate and robust analytical methodology is instrumental to developing orally inhaled and nasal drug products (OINDPs) and their appropriate control programmes. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553258null XML http://www.ptemag.com/pharmtecheurope/analytical+equipment/Monitoring-dissolved-ozone-in-the-pharmaceutical-i/ArticleStandard/Article/detail/553260?ref=25 Emerging technologies now enable continuous on-line monitoring and control of ozone systems, providing precise and reliable results, revolutionizing the way dissolved ozone is measured. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553260null XML http://www.ptemag.com/pharmtecheurope/Latest+News/Is-REACH-coming-to-get-you/ArticleStandard/Article/detail/553785?ref=25 Some chemical substances may no longer be available on the European market if the respective manufacturers and importers fail to preregister with the European Chemicals Agency before 1 December 2008. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/402008/553785null HTML http://www.ptemag.com/pharmtecheurope/APIs/Lets-talk-the-same-language/ArticleStandard/Article/detail/553267?ref=25 The potent nature of HPAPIs means there must be careful evaluation of the compound for its level of toxicity when considering manufacture. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553267null XML http://www.ptemag.com/pharmtecheurope/Outsourcing/CMOs-must-face-new-realities/ArticleStandard/Article/detail/553256?ref=25 CMOs must find new business models and strategies that reflect the many dimensions of the industry's realities... 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553256null XML http://www.ptemag.com/pharmtecheurope/drug+delivery/A-future-without-grey-goo/ArticleStandard/Article/detail/553262?ref=25 Nanoparticles can also cross the blood–brain barrier, which could make them useful for delivering drugs that target brain tumours or diseases that affect the central nervous system. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553262null XML http://www.ptemag.com/pharmtecheurope/Biopharmaceuticals/Successful-strategies-for-product-optimization/ArticleStandard/Article/detail/553264?ref=25 ...an uninformed decision based on commercial requirements alone may, ultimately, have disastrous consequences on the efficacy of the target recombinants. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553264null XML http://www.ptemag.com/pharmtecheurope/Its-a-small-world/ArticleStandard/Article/detail/553255?ref=25 In the popular view of nanomedicine, miniature robots equipped with a set of tools will one day patrol the inside of the body, cleaning up atheroslerotic plaque, zapping cancer cells, and generally performing repair and maintenance. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553255null XML http://www.ptemag.com/pharmtecheurope/drug+delivery/PVA-copolymer-the-new-coating-agent/ArticleStandard/Article/detail/553259?ref=25 The use of PVA copolymer-based film can solve the problems associated with lack of film adhesion... to tablets containing large amounts of waxy excipient or a lubricant. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553259null XML http://www.ptemag.com/pharmtecheurope/Business/Power-to-the-people/ArticleStandard/Article/detail/553266?ref=25 The most public argument against direct-to-consumer advertising in Europe is essentially paternalistic: to protect people from companies who are considered unable to present an objective account of their drugs. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553266null XML http://www.ptemag.com/pharmtecheurope/News/News/ArticleStandard/Article/detail/553254?ref=25 The century old rule of pharmacology that defines how quickly key chemicals pass across cell walls has been challenged by new observations that claim the real transport rates could be up to a hundred times slower than those predicted by Overton's rule. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553254null XML http://www.ptemag.com/pharmtecheurope/Biopharmaceuticals/Bio-news/ArticleStandard/Article/detail/553263?ref=25 n what is believed to be a world first, germ-line transmission from embryonic stem cells in rats has been achieved, which will enable the creation of transgenic rats. The full scientific reports on this breakthrough have been independently verified and submitted to a major scientific journal for publication. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553263null XML http://www.ptemag.com/pharmtecheurope/Validation/Pushing-for-allergen-labelling/ArticleStandard/Article/detail/553257?ref=25 The biggest benefit that has been brought about by the compulsory labelling of allergens in food is the greater degree of cooperation that has been established between food manufacturers and their suppliers. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553257null XML http://www.ptemag.com/pharmtecheurope/Latest+News/Studying-big-eaters-for-better-asthma-treatments/ArticleStandard/Article/detail/553783?ref=25 Studying the role of a particular immune cell in the lungs could lead to better treatments for sufferers of asthma. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/402008/553783null HTML http://www.ptemag.com/pharmtecheurope/Manufacturing+and+Processing/PAT-mdash-a-team-effort/ArticleStandard/Article/detail/553261?ref=25 The biggest benefit of PAT and the current FDA initiatives may be in allowing pharmaceutical scientists to use their technical capabilities to improve pharmaceutical processes. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553261null XML http://www.ptemag.com/pharmtecheurope/Business/Small-company-big-career/ArticleStandard/Article/detail/553265?ref=25 The days of a 'job for life' at a Big Pharma company seem to be well behind us, whether we're at the bench or in the boardroom, but that doesn't mean we should view the employment landscape with trepidation. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553265null XML http://www.ptemag.com/pharmtecheurope/Editor%27s+comment/Business-suicide/ArticleStandard/Article/detail/553253?ref=25 Counterfeiting has become the topic of conversation at all levels of the pharmaceutical industry. Considering the rising number of cases, this is hardly surprising. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/553253null XML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/John-Adkins-151-Sterilin-the-new-independent-compa/ArticleStandard/Article/detail/549231?ref=25 Pharmaceutical Technology Europe interviews John Adkins, CEO of Sterilin Ltd (UK). Sterilin Ltd is the name of the newly formed life sciences company, formerly part of Barloworld Scientific. 2008-10-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/549231null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Instant-pharma-just-add-experts/ArticleStandard/Article/detail/550736?ref=25 In pharma's changing employment, companies that are downsizing still need to ensure they have affordable and reliable access to the right skills at the right time. 2008-09-29T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/550736null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/The-role-of-risk-analysis-in-expanding-business-ac/ArticleStandard/Article/detail/550714?ref=25 Risk management is essential in any successful outsourcing partnership. The key steps towards identifying, understanding and controlling risk are considered. 2008-09-26T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/550714null HTML http://www.ptemag.com/pharmtecheurope/Five-keys-to-reducing-time-to-market/ArticleStandard/Article/detail/552552?ref=25 Five keys to reducing time-to-market 2008-09-24T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552552null PDF http://www.ptemag.com/pharmtecheurope/Finding-the-right-contract-manufacturer/ArticleStandard/Article/detail/552550?ref=25 Contract manufacturing became popular in many industries during the 1990s as a way to counter rising costs and to reinvestment. 2008-09-24T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552550null PDF http://www.ptemag.com/pharmtecheurope/Product-Lifecycle-Management/ArticleStandard/Article/detail/552551?ref=25 Maximizing profit and leveraging innovation 2008-09-24T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552551null PDF http://www.ptemag.com/pharmtecheurope/Innovative-packaging-solutions-to-enhance-patient-/ArticleStandard/Article/detail/552050?ref=25 The right package for your product can increase patient compliance, improve clinical outcomes and boost your sales. With more than 20 years of industry experience and expertise, Catalent offers a comprehensive range of compliance prompting packaging solutions that can be customised to meet your specific demands. 2008-09-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552050null PDF http://www.ptemag.com/pharmtecheurope/Spray-drying-151-Particle-technology-in-the-lab/ArticleStandard/Article/detail/552038?ref=25 Spray drying is a breakthrough particle technology to convert liquids into solid dry powders or microcapsules for applications such as inhalation (pulmonary administration), controlled drug release or microencapsulation. 2008-09-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552038null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Video-games-defeat-supercomputers/ArticleStandard/Article/detail/552036?ref=25 New insight into complex biological systems could be gained by harnessing the power responsible for the graphics in video games. 2008-09-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552036null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/An-uncertain-future-for-biosimilars/ArticleStandard/Article/detail/551094?ref=25 The need to constrain rising pharmaceutical expenditure is driving the growth of biosimilars in Europe and the US, according to a new report by Datamonitor. 2008-09-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/551094null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Worms-basil-and-fake-medicines/ArticleStandard/Article/detail/549363?ref=25 Research into worms, basil and fake medicines were some of highlights of the recent British Pharmaceutical Conference held in Manchester (UK). 2008-09-17T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/549363null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Nature-does-it-best/ArticleStandard/Article/detail/549365?ref=25 The best place to seek novel compounds for pharmaceutical drugs and alternative energy sources, as well as a host of industrial applications, is within natural systems that have evolved over millions of years, according to a recent conference organized by the European Science Foundation, and the European Cooperation in the field of Scientific and Technical Research. 2008-09-16T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/549365null HTML http://www.ptemag.com/pharmtecheurope/Editor%27s+Corner/Battling-counterfeit-pharmaceuticals/ArticleStandard/Article/detail/550486?ref=25 Pharmaceutical counterfeit products are a great threat to consumer safety and a company's reputation. 2008-09-16T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/550486null HTML http://www.ptemag.com/pharmtecheurope/Astell-Scientific-Sterilizers/ArticleStandard/Article/detail/550360?ref=25 With customers including many major Pharmaceutical companies, Astell are experienced in meeting the particular sterilization requirements of this sector. 2008-09-16T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/550360null HTML http://www.ptemag.com/pharmtecheurope/Innovative-packaging-solutions/ArticleStandard/Article/detail/552559?ref=25 The right package for your product can increase patient compliance, improve clinical outcomes - and boost your sales. With more than 20 years of industry experience and expertise, Catalent offers a comprehensive range of compliance prompting packaging solutions that can be customised to meet your specific demands. 2008-09-16T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/392008/552559null PDF http://www.ptemag.com/pharmtecheurope/Out+and+About/Keen-to-be-LEAN/ArticleStandard/Article/detail/549091?ref=25 PTE's Associate editor visits Congleton to learn about the nuts and bolts of Lean Manufacturing. 2008-09-10T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/549091null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Researchers-achieve-direct-cell-transformation/ArticleStandard/Article/detail/547439?ref=25 The ultimate goal of developmental biologists may have been realised by a team that claims to have turned mouse exocrine cells directly into rare insulin-producing beta cells. 2008-09-09T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547439null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Beating-the-blues-by-going-green/ArticleStandard/Article/detail/547438?ref=25 Waste prevention, energy recovery and using fewer raw materials is crucial to saving companies money in the face of economic recession, according to a new report from the UK agency Envirowise. 2008-09-09T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547438null HTML http://www.ptemag.com/pharmtecheurope/Editor%27s+Corner/The-potential-of-PVA-copolymer-capsules/ArticleStandard/Article/detail/550491?ref=25 Polyvinyl alcohol (PVA) copolymer is a relatively new pharmaceutical agent that was registered in the FDA Drug Master File in 2006. 2008-09-08T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/382008/550491null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Erik-Kakes-151-Applikons-big-buyout/ArticleStandard/Article/detail/547598?ref=25 Following the recent announcement of a management buyout at Applikon Biotechnology B.V., Pharmaceutical Technology Europe interviews Erik Kakes, International Sales & Marketing Director Applikon Biotechnology B.V. 2008-09-08T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547598null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Ruediger-Dorn-151-Microsoft-and-BearingPoint-aid-c/ArticleStandard/Article/detail/548490?ref=25 Pharmaceutical Technology Europe interviews Ruediger Dorn, Managing Director, Worldwide Pharmaceutical Industry, Microsoft, after the launch at the beginning of August of the BearingPoint Enterprise Governance, Risk and Compliance (EGRC) solution. 2008-09-08T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/548490null HTML http://www.ptemag.com/pharmtecheurope/Watson-Marlow-Flexible-tubing-151-guaranteed-quali/ArticleStandard/Article/detail/548258?ref=25 Watson-Marlow manufacture high quality tubing for peristaltic pumps and numerous transfer duties, with a choice of 12 different materials for both hygienic use and tough chemical handling. 2008-09-08T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/548258null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Tim-Allsopp-151-worlds-first-authentic-rat-embryon/ArticleStandard/Article/detail/548491?ref=25 Following the recent announcement by Stem Cell Sciences of the creation of the world's first authentic rat embryonic cells, Pharmaceutical Technology Europe interviews Dr Tim Allsopp, Chief Scientific Officer. 2008-09-08T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/372008/548491null HTML http://www.ptemag.com/pharmtecheurope/Editor%27s+comment/Back-to-school/ArticleStandard/Article/detail/547886?ref=25 It's back to school. Another summer has flown past and here we all meet again, ready to return to work and face the winter with renewed energies. Welcome back! 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547886null XML http://www.ptemag.com/pharmtecheurope/Validation/Regulatory-affairs-additional-value/ArticleStandard/Article/detail/547889?ref=25 All commercial sponsors want to maximize their profit and, with a population close to 500 million, the EU is an enormous potential marketplace that they simply cannot ignore! 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547889null XML http://www.ptemag.com/pharmtecheurope/Editor%27s+Corner/The-victory-is-for-India/ArticleStandard/Article/detail/546955?ref=25 n 2007 China was ranked by US consulting firm AT Kearney above India as the most attractive, low-cost location to conduct clinical trials outside the US. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/546955null HTML http://www.ptemag.com/pharmtecheurope/The-winners-circle/ArticleStandard/Article/detail/547898?ref=25 The Pharm Exec 50 report for 2008 accounts for prescription drug sales of more than $510 billion. Interestingly, except for Pfizer, GSK, Sanofi-Aventis (numbers one to three, respectively), and Watson (number 50), every company on the list showed positive growth last year, including some solid double-digit performances. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547898null XML http://www.ptemag.com/pharmtecheurope/analytical+equipment/Pseudo-polymorphic-conversion-by-near-infrared-spe/ArticleStandard/Article/detail/547894?ref=25 Near-infrared spectroscopy (NIR) is suitable for the analysis of pharmaceutical samples in various solid forms, and can be used for determining chemical properties (e.g., content of drug, water), as well as physical properties (e.g., particle size, tablet hardness). 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547894/Woldu_flash.jpg XML http://www.ptemag.com/pharmtecheurope/drug+delivery/Modulation-of-drug-release-from-hydrophilic-matric/ArticleStandard/Article/detail/547891?ref=25 Different chemistries and viscosities of HPMC can be combined to modulate release profile and, in some cases, result in a more robust formulation. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547891/Colorcon_flash.jpg XML http://www.ptemag.com/pharmtecheurope/Biopharmaceuticals/Renaissance-man/ArticleStandard/Article/detail/547899?ref=25 We have to make the politicians understand that if we don't take biotech seriously then tourism will be our premier industry in the future. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547899null XML http://www.ptemag.com/pharmtecheurope/Business/Pharmas-new-winners-and-losers/ArticleStandard/Article/detail/547901?ref=25 Pharmaceuticals used to be such a simple business when everyone knew their place. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547901null XML http://www.ptemag.com/pharmtecheurope/Validation/Effective-complaint-handling-investigations-and-ad/ArticleStandard/Article/detail/547895?ref=25 The challenges of ineffective quality monitoring of complaints, investigations and adverse event reporting can lead to patient harm or death, product withdrawal, and negative financial and brand impact to the organization. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547895/Kopecky_flash.jpg XML http://www.ptemag.com/pharmtecheurope/Validation/Drinking-from-a-fire-hose/ArticleStandard/Article/detail/547893?ref=25 The pharmaceutical industry is facing the perfect storm. Increasing healthcare costs, a changing regulatory environment and vigorous global competition coupled with the increasing complexity of small molecule and biotech drugs contributing to expensive discovery processes and clinical trials, as well as the resultant manufacturing challenges, all pose major threats to the industry. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547893/Venkat_flash.jpg XML http://www.ptemag.com/pharmtecheurope/Analytical/The-counterfeit-detective/ArticleStandard/Article/detail/547890?ref=25 As counterfeiters become more cunning and technologically advanced, spotting their handiwork is increasingly difficult. Can surface analysis techniques be used to outwit them? 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547890null XML http://www.ptemag.com/pharmtecheurope/Manufacturing+and+Processing/Bruce-Davies/ArticleStandard/Article/detail/547902?ref=25 Pharmaceutical Technology Europe interviews Bruce Davis, Chairman of the International Society for Pharmaceutical Engineering Board (ISPE), the world's largest not-for-profit association dedicated to educating and advancing pharmaceutical manufacturing professionals and their industry. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547902null XML http://www.ptemag.com/pharmtecheurope/analytical+equipment/The-importance-of-stage-mensuration-for-cascade-im/ArticleStandard/Article/detail/547892?ref=25 Cascade impaction data characterizes all inhalation products, making the performance of impactors an important issue for the pharmaceutical sector. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547892/Copley_flash.jpg XML http://www.ptemag.com/pharmtecheurope/Testing-time-for-stem-cells/ArticleStandard/Article/detail/547888?ref=25 Researchers at Children's Hospital Boston (MA, USA) recently announced another group of stem cells that can produce cardiomyocytes (heart muscle cells). It seems hardly a month goes by without some kind of discovery in the fast-moving world of stem cells. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547888null XML http://www.ptemag.com/pharmtecheurope/News/News/ArticleStandard/Article/detail/547887?ref=25 Lack of measureable decline in memory and thinking processes among placebo groups in Alzheimer's disease clinical trials could reduce the ability to show the effectiveness of new therapies, according to new research unveiled at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease held in Chicago (IL, USA). Alzheimer's clinical trials seek to demonstrate that those receiving the treatment improved during the course of the study when compared with those that received placebo, or that their condition became worse to a lesser degree. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547887null XML http://www.ptemag.com/pharmtecheurope/analytical+equipment/Bioanalysis-of-recombinant-proteins-by-mass-spectr/ArticleStandard/Article/detail/547897?ref=25 Biotechnological developments have led to an increased number of recombinant proteins or antibodies in drug development that offer high potential in various diseases, such as cancer, growth disturbances and diabetes. 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547897/Ezan_flash.jpg XML http://www.ptemag.com/pharmtecheurope/Validation/Joining-the-parallel-lines/ArticleStandard/Article/detail/547900?ref=25 ...some companies complained that what they received was not joint advice or combined advice but parallel advice, without coherence... 2008-09-01T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/362008/547900null XML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Fraser-Black-151-know-your-assets/ArticleStandard/Article/detail/542496?ref=25 Many interesting subjects were covered at the ERBI Conference that took place in Cambridge (UK) in May, including treating cancer and the future of antibodies. Arguably the most important point discussed, however, was reducing costs. 2008-08-29T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/542496null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Collaboration-to-discover-anti-cancer-compounds/ArticleStandard/Article/detail/546102?ref=25 A leading pharmaceutical company has teamed up with the National Cancer Centre Singapore along with Singapore's National University Hospital to develop anticancer compounds. AstraZeneca signed the Memorandum of Understanding (MOU) with the two institutes in the hope of further building its drug development capabilities in Asia as well as, ultimately, speeding up access to new medicines of potential benefit to patients with inoperable Hepatocellular Carcinoma (HCC). 2008-08-29T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/546102null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Andrew-Hughes-from-AstraZeneca-151-Singapore-colla/ArticleStandard/Article/detail/546103?ref=25 Pharmaceutical Technology Europe interviews Andrew Hughes, Discovery Medicine Director Clinical Oncology, at AstraZeneca (UK). 2008-08-29T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/546103null HTML http://www.ptemag.com/pharmtecheurope/Head-of-the-Laboratory-Department/ArticleStandard/Article/detail/545308?ref=25 Council of Europe: Head of the Laboratory Department 2008-08-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/545308null PDF http://www.ptemag.com/pharmtecheurope/Latest+News/Breaking-the-rules/ArticleStandard/Article/detail/545346?ref=25 The century old rule of pharmacology that defines how quickly key chemicals can pass across cell walls has been challenged by new observations that claim the real transport rates could be up to a hundred times slower than those predicted by Overton's rule. 2008-08-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/545346null HTML http://www.ptemag.com/pharmtecheurope/Head-of-the-European-Pharmacopoeia-Department/ArticleStandard/Article/detail/545306?ref=25 Council of Europe: Head of the European Pharmacopoeia Department 2008-08-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/545306null PDF http://www.ptemag.com/pharmtecheurope/Editor%27s+Corner/PEG-to-the-rescue/ArticleStandard/Article/detail/545310?ref=25 Many biopharmaceuticals suffer from problems associated with short half-lives, immunogenicity, and poor stability and solubility but the performance of many small molecules and macromolecules (peptides, proteins) can be improved using the polymer polyethylene glycol (PEG), which has been hailed as the wonder polymer of the biopharmaceutical world. 2008-08-27T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/545310null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Patrick-Unwin-151-overturning-the-rules-of-chemist/ArticleStandard/Article/detail/545304?ref=25 Pharmaceutical Technology Europe interviews Professor Patrick Unwin from the Department of Chemistry at the University of Warwick (UK). 2008-08-27T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/352008/545304null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Say-hello-to-safe-and-synthetic-heparin/ArticleStandard/Article/detail/543601?ref=25 Has a purer and safer alternative to heparin been created? Robert Linhardt, Professor of Biocatalysis and Metabolic Engineering at the Rensselaer Polytechnic Institute (NY, USA), seems to think so after he and his team created a large dose of synthetic heparin in the laboratory; the largest dose that has ever been created. 2008-08-26T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/342008/543601null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Are-drug-life-cycles-evolving-for-the-worst/ArticleStandard/Article/detail/543600?ref=25 Drug product cycles are becoming shorter and shorter with lower peak sales as competitive pressure mounts from the post-patented-expiry entry of generics and the market entry of new brands, according to Datamonitor. 2008-08-26T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/342008/543600null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Fooling-TB-with-a-food-additive/ArticleStandard/Article/detail/542453?ref=25 Swiss researchers believe they have found a way to make the antibiotic Ethionamid more effective against a strain of TB that is estimated by the World Health Organization to affect 50 million people worldwide. 2008-08-20T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/542453null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Biotech-goes-for-industry-domination/ArticleStandard/Article/detail/542452?ref=25 Biotech drugs are invading an increasing amount of therapeutic areas and account for nearly 50% of all oncology and blood disorder applications, according to a report from the Italian Chemical Pharmaceutical Association. 2008-08-20T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/542452null HTML http://www.ptemag.com/pharmtecheurope/Online+Exclusives/Thomas-Eldered-151-Recipharm/ArticleStandard/Article/detail/543658?ref=25 Pharmaceutical Technology Europe interviews Thomas Eldered, CEO and Managing Director of Recipharm AB, a leading contract development and manufacturing organization based in Europe. 2008-08-20T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/342008/543658null HTML http://www.ptemag.com/pharmtecheurope/Pharmas-new-winners-and-losers/ArticleStandard/Article/detail/543345?ref=25 In her new column for Pharmaceutical Technology Europe?s Business Focus, acclaimed healthcare writer Jacky Law looks at why, from a company perspective, bigger isn?t necessarily better in the evolving pharma landscape. 2008-08-19T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/342008/543345null HTML http://www.ptemag.com/pharmtecheurope/Editor%27s+Corner/Out-of-REACH/ArticleStandard/Article/detail/543666?ref=25 Are you a manufacturer of excipients or APIs? Are you based in or import your products to Europe? REACH may be coming to get you... 2008-08-18T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/342008/543666null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/PTE-partners-with-Chemspec-Europe/ArticleStandard/Article/detail/542307?ref=25 Introducing the new media partnership between Pharmaceutical Technology Europe and Chemspec Europe. On 17?18 June 2009, Chemspec Europe will take place in Spain for the first time and will be partnered by PTE. 2008-08-14T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/542307null HTML http://www.ptemag.com/pharmtecheurope/Aiding-AIDS/ArticleStandard/Article/detail/535255?ref=25 The importance of scaling-up AIDS programmes and strengthening health systems in poor countries has been highlighted by speakers at the XVII International AIDS conference held in Mexico earlier this month. 2008-08-13T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/535255null HTML http://www.ptemag.com/pharmtecheurope/Asia-rises-above-Europe/ArticleStandard/Article/detail/535256?ref=25 Oncology clinical trials conducted in Europe are decreasing as Asia becomes the new hotspot, according to an analysis by Citeline (NY, USA), with South Korea seeing the largest gains in oncology trial sites in 2007 compared with figures for 2004. 2008-08-13T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/535256null HTML http://www.ptemag.com/pharmtecheurope/Survey-Results-151-If-you-could-change-one-aspect-/ArticleStandard/Article/detail/535299?ref=25 survey results 2008-08-11T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/332008/535299null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Team-FDAEMEA/ArticleStandard/Article/detail/533474?ref=25 Further details have emerged regarding the agreement made for increased collaboration between FDA and EMEA. 2008-08-06T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/322008/533474null HTML http://www.ptemag.com/pharmtecheurope/Product-profile-Celsis/ArticleStandard/Article/detail/534140?ref=25 Celsis product profile. 2008-08-05T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/322008/534140null HTML http://www.ptemag.com/pharmtecheurope/Event-profile-BIO-Europe-2008/ArticleStandard/Article/detail/534139?ref=25 EBD event profile 2008-08-05T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/322008/534139null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/How-virtual-babies-can-save-12810000/ArticleStandard/Article/detail/533462?ref=25 The use of virtual studies in children could soon become routine during drug development as new EU legislation seeks to address the issue that more than 50% of the medicines currently used in children have not been officially tested in this age group. 2008-08-04T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/322008/533462null HTML http://www.ptemag.com/pharmtecheurope/ISO27001-Certification/ArticleStandard/Article/detail/533470?ref=25 It Governance smoothes the way to ISO27001 certification for IMS Hospital Group 2008-08-04T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/322008/533470null PDF http://www.ptemag.com/pharmtecheurope/Latest+News/A-sweetener-for-stem-cell-science/ArticleStandard/Article/detail/531981?ref=25 Funding worth the equivalent of €467000 could help scientists at the University of Manchester (UK) discover how the body's natural sugars can be used to create stem cell treatments for heart disease and nerve damage. 2008-07-30T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531981null HTML http://www.ptemag.com/pharmtecheurope/A-warring-success/ArticleStandard/Article/detail/532975?ref=25 The UK biotech industry significantly lags behind its US counterpart in business success, according to results from a wargame commissioned by the Bioscience Futures Forum (UK). 2008-07-30T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532975null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Licking-your-wounds/ArticleStandard/Article/detail/531983?ref=25 A compound in human saliva that accelerates wound healing could offer hope to sufferers of chronic wounds. 2008-07-30T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531983null HTML http://www.ptemag.com/pharmtecheurope/Survey-results-151-Do-you-think-the-Big-Pharma-col/ArticleStandard/Article/detail/531987?ref=25 survey results. 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531987null HTML http://www.ptemag.com/pharmtecheurope/Survey-results-151-Is-job-security-a-concern-for-y/ArticleStandard/Article/detail/531986?ref=25 SAurvey results. 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531986null HTML http://www.ptemag.com/pharmtecheurope/Introducing-an-automated-and-validated-calibration/ArticleStandard/Article/detail/532025?ref=25 AstraZeneca Sweden Operations 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532025null PDF http://www.ptemag.com/pharmtecheurope/Survey-results-151-should-more-be-done-to-make-it-/ArticleStandard/Article/detail/532711?ref=25 Survey results 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532711null HTML http://www.ptemag.com/pharmtecheurope/Survey-results-151-PTEs-August-issue-is-an-online-/ArticleStandard/Article/detail/531989?ref=25 Survey results 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531989null HTML http://www.ptemag.com/pharmtecheurope/IT-Governance-smoothes-the-way-to-IS027001-certifi/ArticleStandard/Article/detail/531976?ref=25 IT Governance smoothes the way to IS027001 certification for IMS Hospital Group. 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531976null PDF http://www.ptemag.com/pharmtecheurope/Scientific-Assistants-151-Certification-Division/ArticleStandard/Article/detail/532013?ref=25 Scientific Assistants — Certification Division 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532013null PDF http://www.ptemag.com/pharmtecheurope/Survey-results-151-Could-playing-wargames-improve-/ArticleStandard/Article/detail/531988?ref=25 Survey results. 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/531988null HTML http://www.ptemag.com/pharmtecheurope/Survey-results-151-biobanks-are-we-becoming-a-Big-/ArticleStandard/Article/detail/532707?ref=25 Survey results 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532707null HTML http://www.ptemag.com/pharmtecheurope/11000-calibrations-a-year-made-mostly-with-Beamex-/ArticleStandard/Article/detail/532027?ref=25 Eli Lilly and Compny Limited, Speke Operations United Kingdom 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532027null PDF http://www.ptemag.com/pharmtecheurope/Flexibility-in-calibration-management/ArticleStandard/Article/detail/532028?ref=25 TEVA UK Limited United Kingdom 2008-07-28T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/312008/532028null PDF http://www.ptemag.com/pharmtecheurope/Latest+News/Is-pharmas-doomsday-nigh/ArticleStandard/Article/detail/531125?ref=25 New analysis by Informa Pharmaof the current state of the pharma industry paints a bleak picture for the future of some of the industry's largest companies as the threat of patent expiries and empty pipelines hangs above them. 2008-07-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/302008/531125null HTML http://www.ptemag.com/pharmtecheurope/Paperless-calibaration-system-151-the-choice-of-an/ArticleStandard/Article/detail/531296?ref=25 Paperless calibaration system — the choice of an enviornmentally conscious pharmaceutical company 2008-07-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/302008/531296null PDF http://www.ptemag.com/pharmtecheurope/Modular-Cleanroom-Construction-Makes-the-Differenc/ArticleStandard/Article/detail/531297?ref=25 Modular Cleanroom Construction Makes the Difference at St. Georges Hospital 2008-07-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/302008/531297null PDF http://www.ptemag.com/pharmtecheurope/Latest+News/The-positive-side-of-side-effects/ArticleStandard/Article/detail/531123?ref=25 New uses for existing drugs could be predicted from their side-effects, according to researchers at the European Molecular Biology Laboratory (EMBL). 2008-07-23T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/302008/531123null HTML http://www.ptemag.com/pharmtecheurope/Latest+News/Big-Pharma-joins-forces/ArticleStandard/Article/detail/529365?ref=25 Three of the world?s largest pharmaceutical companies will collaborate as they attempt to solve the innovation draught that appears to be sweeping across the pharmaceutical industry. 2008-07-16T04:00:00Z http://www.ptemag.com/pharmtecheurope/data/articlestandard/pharmtecheurope/292008/529365null HTML