Developing cold chain solutions

20th Anniversary Special Feature: Two decades of packaging development

Twenty years ago it was commonplace for pills, tablets and capsules to come in small, plastic or even glass bottles. Syrups were a much more common galenic solution than today, and individual dosages of injectables were only offered in glass vials and ampoules.

Transdermal film containing nicotine and bupropion for combined smoking cessation therapy

Testing Inhalers

This article investigates how the industry can test inhalers in a way that is most representative of typical use.

Dry powder inhalers: challenges and goals for next generation therapies

There have been significant advances, especially in understanding the role of carrier properties on the aerosol performance of the API.

Microstructured transdermal systems for intradermal vaccine and drug delivery

The needle and syringe have long been the standard delivery technology for vaccines. However, a confluence of market factors is driving new interest in alternative delivery systems that hold the potential to meet one or more of the following goals: improved antigen utilization, higher quality immune response, better stability and improved patient acceptance. Of particular interest are microneedle systems, otherwise referred to as microstuctured transdermal systems (MTS), that provide for targeted delivery of the vaccine formulation directly to antigen-presenting cells within the epidermis. This article provides a brief overview of MTS technology with an emphasis on solid-coated MTS for vaccine delivery.