Drug Development - Analytical - Pharm Tech Europe
 

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Jul 4, 2009

Drug Development - Analytical

Quick API delivery

01 October 2007

The authors consider the advantages of using rapidly dissolving films to accurately and effectively deliver pharmaceutical ingredients, with an emphasis on the importance of controlling moisture content and drug loading during formulation development.

A partially freeze-dried lyophilization technology for producing fast-melting tablets

01 September 2007

A new economical method for producing fast-melting lamina-like dosage forms.

Testing Inhalers

01 September 2007

This article investigates how the industry can test inhalers in a way that is most representative of typical use.

A Raman spectroscopic method to monitor magnesium stearate in blends and tablets

01 September 2007

A new Raman spectroscopic method to detect magnesium stearate in powder blends and tablets is described. High-volume pharmaceutical manufacturing requires the use of lubricants to facilitate tablet ejection from compressing machines. However, lubricants may also bring a number of undesired problems that have been widely documented in pharmaceutical scientific literature. New analytical methods are needed to understand lubrication and provide process knowledge in support of FDA's process analytical technology initiative. The detection of magnesium stearate in lactose, mannitol, corn starch and other commercially important excipients is reported. The Raman spectroscopic method has a detection limit of about 0.1% (w/w) based on the 2848 cm-1 band that corresponds to the symmetric stretch of the methylene group in magnesium stearate.

Predicting powder flow

01 June 2007

Predicting the flow characteristics of powders during manufacture is especially important for the pharmaceutical engineer. Getting the powder flow wrong can be highly disruptive to plant performance and productivity, particularly where equipment has to be taken off-line and stripped down for cleaning out blockages. The flow behaviour of the individual ingredients may be well known, but as these are blended and reacted their flow properties can change.

Developments in particle engineering processes for pharmaceutical drug delivery systems

01 May 2007

One of the major concerns with introducing PAT, however, is that the bias towards process engineering may not ultimately lead to complete control of product quality.

Polymers for CNS drug delivery

01 May 2007

There is a tremendous need to enhance delivery of potential therapeutics to the brain for treatment of central nervous system (CNS) disorders. The blood brain barrier (BBB) restricts and controls the exchange of compounds between the CNS and the blood, which requires discovery of new modalities allowing for effective drug delivery to the CNS. Polymer nanotechnology has now become one of the most attractive areas of pharmaceutical research. This review focuses on the current progress in polymeric nanoparticles, where the specific arrangement of the polymeric matter at the nanoscale is utilized to design drug delivery systems that provide safe and efficient transport of CNS drugs across the BBB.

Greener, cleaner and leaner

01 May 2007

Green chemistry involves redesigning processes so that more of the raw material ends up in the product, rather than as waste...

Dry powder inhalers: challenges and goals for next generation therapies

01 April 2007

There have been significant advances, especially in understanding the role of carrier properties on the aerosol performance of the API.

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